AMP; Dermatan sulfate - urine; Urine heparan sulfate; Urine dermatan sulfate; Heparan sulfate - urine
Acid mucopolysaccharides is a test that measures the amount of mucopolysaccharides released into the urine either on 1 episode or over a 24-hour period.
Mucopolysaccharides are long chains of sugar molecules in the body. They are often found in mucus and in fluid around the joints.
For the 24-hour test, you must urinate into a special bag or container every time you use the bathroom.
For an infant:
Thoroughly wash the area around the urethra (the hole where urine flows out). Open a urine collection bag (a plastic bag with an adhesive paper on one end).
Check the infant often, and change the bag after the infant has urinated. Empty the urine from the bag into the container provided by your doctor.
Active babies can move the bag causing the urine to go into the diaper. You may need extra collection bags.
When finished, label the container and return it as you have been told.
There is no special preparation needed.
The test involves only normal urination, and there is no discomfort.
This test is done to diagnose a rare group of genetic disorders called mucopolysaccharidoses (MPS). These include, Hurler, Scheie, and Hurler/Scheie syndromes (MPS I), Hunter syndrome (MPS II), Sanfilippo syndrome (MPS III), Morquio syndrome (MPS IV), Maroteaux-Lamy syndrome (MPS VI), and Sly syndrome (MPS VII).
Most of the time, this test is done in infants who may have a symptom or family history of one of these disorders.
Normal levels vary with age and from lab to lab. Talk to your doctor about the meaning of your specific test results.
Abnormally high levels could be consistent with a type of mucopolysaccharidosis. Further tests are needed to determine the specific type of mucopolysaccharidosis.
Jones KL, Jones MC, Del Campo M. Storage disorders. In: Jones KL, Jones MC, Del Campo M eds. Smith's Recognizable Patterns of Human Malformation. 7th ed. Philadelphia, PA: Elsevier Saunders; 2013:chap O.BACK TO TOP
Review Date: 4/20/2015
Reviewed By: Chad Haldeman-Englert, MD, FACMG, Wake Forest School of Medicine, Department of Pediatrics, Section on Medical Genetics, Winston-Salem, NC. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
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