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Muscle biopsy

Biopsy - muscle


A muscle biopsy is the removal of a small piece of muscle tissue for examination.

How the Test is Performed


This procedure is usually done while you are awake. The health care provider will apply a numbing medicine (local anesthesia) to the biopsy area.

There are two types of muscle biopsy:

A needle biopsy involves inserting a needle into the muscle. When the needle is removed, a small piece of tissue remains in the needle. More than one needle stick may be needed to get a large enough sample.

An open biopsy involves making a small cut in the skin and into the muscle. The muscle tissue is then removed.

After either type of biopsy, the tissue is sent to a laboratory for examination.


How to Prepare for the Test


No special preparation is usually needed. If you will have anesthesia, follow instructions on not eating or drinking anything before the test.


How the Test will Feel


During the biopsy, there is usually little or no discomfort. You may feel some pressure or tugging.

The anesthetic may burn or sting when injected (before the area becomes numb). After the anesthetic wears off, the area may be sore for about a week.


Why the Test is Performed


A muscle biopsy may be done to identify or detect:

  • Diseases of the connective tissue and blood vessels (such as polyarteritis nodosa)
  • Infections that affect the muscles (such as trichinosis or toxoplasmosis)
  • Muscle disorders such as muscular dystrophy or congenital myopathy
  • Metabolic defects of the muscle

A muscle biopsy may also be done to tell the difference between nerve and muscle disorders.

A muscle that has recently been injured, such as by an EMG needle, or is affected by a pre-existing condition, such as nerve compression, is not a good choice for a biopsy.


Normal Results


A normal result means the muscle is normal.


What Abnormal Results Mean


A muscle biopsy can help diagnose the following conditions:

  • Atrophy (loss of muscle mass)
  • Dermatomyositis
  • Duchenne muscular dystrophy
  • Inflammation of the muscle
  • Muscular dystrophy
  • Myopathic changes (destruction of the muscle)
  • Necrosis (tissue death) of muscle
  • Necrotizing vasculitis
  • Traumatic muscle damage
  • Polymyositis

Additional conditions under which the test may be performed include:

  • Becker muscular dystrophy
  • Charcot-Marie-Tooth disease (hereditary)
  • Common peroneal nerve dysfunction
  • Eosinophilic fasciitis
  • Facioscapulohumeral muscular dystrophy (Landouzy-Dejerine)
  • Familial periodic paralysis
  • Friedreich ataxia
  • Polymyalgia rheumatica
  • Senile cardiac amyloid
  • Thyrotoxic periodic paralysis




The risks are small, but may include:

  • Bleeding
  • Bruising
  • Damage to the muscle tissue or other tissues in the area (very rare)
  • Infection (a slight risk any time the skin is broken)




Shepich JR. Muscle biopsy. In: Pfenninger JL, Fowler GC, eds. Pfenninger & Fowler's Procedures for Primary Care. 3rd ed. Philadelphia, PA: Elsevier Mosby; 2010:chap 228.

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          Review Date: 9/8/2014

          Reviewed By: C. Benjamin Ma, MD, Assistant Professor, Chief, Sports Medicine and Shoulder Service, UCSF Department of Orthopaedic Surgery, San Francisco, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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